The Rheumatology Department of Hospital Universitario Puerta de Hierro has a long tradition of basic and translational research into different aspects of the immune response and the aetiopathogenesis of systemic autoimmune diseases. In recent years, our group has mainly dedicated its activity to the development of clinical-genetic models predicting prognosis, progression and therapeutic response in various immune-mediated inflammatory diseases, such as rheumatoid arthritis or ankylosing spondylitis, as a basis for the development of personalised medicine. It has taken part in various projects subject to competitive public funding, such as the Proyecto Singular Osagen (PSE01000-2006-1) “Biotechnology applied to the development of new diagnostic and prognostic tools for complex diseases”, a national multicentre project funded by the Ministry of Education and Science, or the FIS Project (PI11/00400) “Functional implications of single nucleotide polymorphisms (SNPs) associated with ankylosing spondylitis”, funded by the Instituto de Salud Carlos III. It has also had the opportunity to take part in the RIER Network for the Study of rheumatological and inflammatory diseases, establishing collaborations with the groups of Dr López de Castro from CBMSO and Dr Mellado from CNB-CSIC, or the group of Dr López Larrea from H.U. Central de Asturias. Our group also actively collaborates with the Sociedad Española de Reumatología (SER), taking part in various research projects and national patient registries, such as the Registry of patients with spondyloarthritis (REGISPONSER), the Esperanza project for the diagnosis and follow-up of recent-onset spondyloarthritis, in patients with systemic Lupus Erythematosus (RELESSER project), patients with primary Sjögren's syndrome (SJOGRENSER), the GEACSER project, for the study of microcrystal-induced inflammatory diseases, or the GUIPCLINGOT Project, for carrying out clinical and epidemiological studies of patients diagnosed with gout. Doctoral theses have also been developed in the group by resident medical interns from the Rheumatology Department, such as the one presented last year, 2017, entitled: “Clinical, biological and genetic factors associated with response to anti-TNFα drugs in patients with ankylosing spondylitis, non-radiographic axial spondyloarthritis and psoriatic arthritis” or the one currently being developed entitled: “Association of capillaroscopic patterns and intraplatelet angiogenesis biomarkers in patients with systemic sclerosis and pulmonary involvement”. Our group actively takes part through lectures, presentations and poster displays at both international (EULAR, ACR) and national (SER national congress, SORCOM congress) conferences, and has a relevant scientific output resulting from the outcomes of its research activity and established collaborations.