{"id":6066,"date":"2026-08-25T13:22:48","date_gmt":"2026-08-25T11:22:48","guid":{"rendered":"http:\/\/localhost\/idiphisa-nueva-web-2\/?page_id=6066"},"modified":"2026-08-25T13:22:48","modified_gmt":"2026-08-25T11:22:48","slug":"method-for-identifying-lung-cancer-patients-for-a-combination-treatment-of-immuno-and-chemotherapy","status":"publish","type":"page","link":"https:\/\/investigacionpuertadehierro.com\/en\/unidad-de-apoyo-tecnico-a-la-innovacion\/method-for-identifying-lung-cancer-patients-for-a-combination-treatment-of-immuno-and-chemotherapy\/","title":{"rendered":"Method for identifying lung cancer patients for a combination treatment of immuno- and chemotherapy"},"content":{"rendered":"<div class=\"wp-block-greenshift-blocks-row gspb_row gspb_row-id-gsbp-c4ea3b4\" id=\"gspb_row-id-gsbp-c4ea3b4\"><div class=\"gspb_row__content\"> \n<div class=\"wp-block-greenshift-blocks-row-column gspb_row__col--4 gspb_col-id-gsbp-47414aa\" id=\"gspb_col-id-gsbp-47414aa\">\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"369\" height=\"130\" src=\"https:\/\/investigacionpuertadehierro.com\/wp-content\/uploads\/2026\/08\/nivo.png\" alt=\"\" class=\"wp-image-6067\" srcset=\"https:\/\/investigacionpuertadehierro.com\/wp-content\/uploads\/2026\/08\/nivo.png 369w, https:\/\/investigacionpuertadehierro.com\/wp-content\/uploads\/2026\/08\/nivo-300x106.png 300w\" sizes=\"auto, (max-width: 369px) 100vw, 369px\" \/><\/figure>\n\n\n\n<h4 id=\"gspb_heading-id-gsbp-9d117f0\" class=\"gspb_heading gspb_heading-id-gsbp-9d117f0\"><strong>R&amp;D&amp;I result<\/strong><\/h4>\n\n\n\n<div class=\"wp-block-greenshift-blocks-row gspb_row gspb_row-id-gsbp-9c5e8bd\" id=\"gspb_row-id-gsbp-9c5e8bd\"><div class=\"gspb_row__content\"> \n<div class=\"wp-block-greenshift-blocks-row-column gspb_row__col--9 gspb_col-id-gsbp-e677074\" id=\"gspb_col-id-gsbp-e677074\">\n<p class=\"wp-block-paragraph\" style=\"margin-top:0px;margin-bottom:0px\">Patent<\/p>\n\n\n\n<p class=\"wp-block-paragraph\" style=\"margin-top:0px;margin-bottom:0px\">PCT\/EP2023\/055598<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-greenshift-blocks-row-column gspb_row__col--3 gspb_col-id-gsbp-f5c5ec0\" id=\"gspb_col-id-gsbp-f5c5ec0\">\n<figure class=\"wp-block-image alignfull size-full\" style=\"margin-top:0px;margin-right:0px;margin-bottom:0px;margin-left:0px\"><a href=\"https:\/\/worldwide.espacenet.com\/patent\/search\/family\/082701771\/publication\/WO2024017510A1?q=PCT%2FEP2023%2F055598\" target=\"_blank\" rel=\" noopener\"><img loading=\"lazy\" decoding=\"async\" width=\"55\" height=\"56\" src=\"https:\/\/investigacionpuertadehierro.com\/wp-content\/uploads\/2026\/08\/vinculo.png\" alt=\"\" class=\"wp-image-6042\" style=\"object-fit:cover\"\/><\/a><\/figure>\n<\/div>\n <\/div><\/div>\n\n\n\n<div class=\"wp-block-stackable-divider stk-block-divider stk-block stk-1171c16\" data-block-id=\"1171c16\"><style>.stk-1171c16 {margin-top:10px !important;margin-bottom:10px !important;}<\/style><hr class=\"stk-block-divider__hr\"\/><\/div>\n\n\n\n<h4 id=\"gspb_heading-id-gsbp-3cde8ed\" class=\"gspb_heading gspb_heading-id-gsbp-3cde8ed\"><strong>Colaboraci\u00f3n<\/strong><\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">Technology available for licensing<\/p>\n\n\n\n<div class=\"wp-block-stackable-divider stk-block-divider stk-block stk-5b6b8b7\" data-block-id=\"5b6b8b7\"><style>.stk-5b6b8b7 {margin-top:10px !important;margin-bottom:10px !important;}<\/style><hr class=\"stk-block-divider__hr\"\/><\/div>\n\n\n\n<h4 id=\"gspb_heading-id-gsbp-c794fcd\" class=\"gspb_heading gspb_heading-id-gsbp-c794fcd\"><strong>Contact<\/strong><\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">Innovation Support Unit<br>Instituto de Investigaci\u00f3n Sanitaria Puerta de Hierro<br><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>T: +34 91 191 69 37<\/li>\n\n\n\n<li>E:&nbsp;<a href=\"mailto:unidadinnovacion@idiphim.org\">unidadinnovacion@idiphim.org<\/a><\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><a href=\"https:\/\/investigacionpuertadehierro.com\/en\/common-platforms\/unidad-de-apoyo-a-la-innovacion\/\">https:\/\/investigacionpuertadehierro.com\/plataformas-comunes\/unidad-de-apoyo-a-la-innovacion<\/a><\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-greenshift-blocks-row-column gspb_row__col--8 gspb_col-id-gsbp-fbaaa4b\" id=\"gspb_col-id-gsbp-fbaaa4b\"><h2 class=\"wp-block-post-title\">Method for identifying lung cancer patients for a combination treatment of immuno- and chemotherapy<\/h2>\n\n\n<h6 id=\"inventores\" class=\"wp-block-heading\"><strong><em>Inventors<\/em><\/strong><\/h6>\n\n\n\n<p class=\"wp-block-paragraph\">Atocha Romero Alfonso; Roberto Serna Blasco; Mariano Provencio Pulla<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Fundaci\u00f3n para la Investigaci\u00f3n Biom\u00e9dica del Hospital Universitario Puerta del Hierro (FIBHUPHM); Universidad Aut\u00f3noma de Madrid; Fundaci\u00f3n GECP.<\/p>\n\n\n\n<h6 id=\"antecedentes\" class=\"wp-block-heading\"><strong><em>Background<\/em><\/strong><\/h6>\n\n\n\n<p class=\"wp-block-paragraph\">The availability of biomarkers that predict response to treatment is essential for the development of personalized medicine, avoiding ineffective treatments and unnecessary toxicities in non-responder patients, thus allowing efficient management of these drugs, which have a high economic impact. On the other hand, identifying patients at higher risk of disease progression or relapse can help to tailor subsequent treatments based on this risk, in this sense it is possible to adjust the doses or duration of treatments or plan subsequent lines of treatment, prioritizing the course of the disease, thus allowing for rapid and effective management of these patients.<\/p>\n\n\n\n<h6 id=\"la-invencion\" class=\"wp-block-heading\"><strong><em>La invenci\u00f3n<\/em><\/strong><\/h6>\n\n\n\n<p class=\"wp-block-paragraph\">The present invention relates in one aspect to&nbsp;<strong>an&nbsp;<\/strong><strong><em>in vitro<\/em><\/strong><strong>&nbsp;method for identifying a subject suitable for treatment with a combination of immunotherapy and chemotherapy<\/strong>, comprising determining the absence of a somatic mutation in at least two of the genes EGFR, KMT2C, APC, ERBB3, and HNF1A, and\/or the absence of a germline mutation in PBRM1 in a biological sample from the subject, wherein the subject is afflicted with cancer.<\/p>\n<\/div>\n 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