{"id":6053,"date":"2026-08-25T13:05:27","date_gmt":"2026-08-25T11:05:27","guid":{"rendered":"http:\/\/localhost\/idiphisa-nueva-web-2\/?page_id=6053"},"modified":"2026-08-25T13:05:27","modified_gmt":"2026-08-25T11:05:27","slug":"granulisina-metodo-de-obtencion-y-usos","status":"publish","type":"page","link":"https:\/\/investigacionpuertadehierro.com\/en\/unidad-de-apoyo-tecnico-a-la-innovacion\/granulisina-metodo-de-obtencion-y-usos\/","title":{"rendered":"Granulysin, method of obtaining it and uses"},"content":{"rendered":"<div class=\"wp-block-greenshift-blocks-row gspb_row gspb_row-id-gsbp-c4ea3b4\" id=\"gspb_row-id-gsbp-c4ea3b4\"><div class=\"gspb_row__content\"> \n<div class=\"wp-block-greenshift-blocks-row-column gspb_row__col--4 gspb_col-id-gsbp-47414aa\" id=\"gspb_col-id-gsbp-47414aa\">\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"981\" height=\"486\" src=\"https:\/\/investigacionpuertadehierro.com\/wp-content\/uploads\/2026\/08\/Granulisina.png\" alt=\"\" class=\"wp-image-6054\" srcset=\"https:\/\/investigacionpuertadehierro.com\/wp-content\/uploads\/2026\/08\/Granulisina.png 981w, https:\/\/investigacionpuertadehierro.com\/wp-content\/uploads\/2026\/08\/Granulisina-300x149.png 300w, https:\/\/investigacionpuertadehierro.com\/wp-content\/uploads\/2026\/08\/Granulisina-767x380.png 767w\" sizes=\"auto, (max-width: 981px) 100vw, 981px\" \/><\/figure>\n\n\n\n<h4 id=\"gspb_heading-id-gsbp-9d117f0\" class=\"gspb_heading gspb_heading-id-gsbp-9d117f0\"><strong>R&amp;D&amp;I result<\/strong><\/h4>\n\n\n\n<div class=\"wp-block-greenshift-blocks-row gspb_row gspb_row-id-gsbp-9c5e8bd\" id=\"gspb_row-id-gsbp-9c5e8bd\"><div class=\"gspb_row__content\"> \n<div class=\"wp-block-greenshift-blocks-row-column gspb_row__col--9 gspb_col-id-gsbp-e677074\" id=\"gspb_col-id-gsbp-e677074\">\n<p class=\"wp-block-paragraph\" style=\"margin-top:0px;margin-bottom:0px\">Patent <\/p>\n\n\n\n<p class=\"wp-block-paragraph\" style=\"margin-top:0px;margin-bottom:0px\">WO2020020978A1<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-greenshift-blocks-row-column gspb_row__col--3 gspb_col-id-gsbp-f5c5ec0\" id=\"gspb_col-id-gsbp-f5c5ec0\">\n<figure class=\"wp-block-image alignfull size-full\" style=\"margin-top:0px;margin-right:0px;margin-bottom:0px;margin-left:0px\"><a href=\"https:\/\/worldwide.espacenet.com\/patent\/search\/family\/067441137\/publication\/WO2020020978A1?q=pn%3DWO2020020978A1\" target=\"_blank\" rel=\" noopener\"><img loading=\"lazy\" decoding=\"async\" width=\"55\" height=\"56\" src=\"https:\/\/investigacionpuertadehierro.com\/wp-content\/uploads\/2026\/08\/vinculo.png\" alt=\"\" class=\"wp-image-6042\" style=\"object-fit:cover\"\/><\/a><\/figure>\n<\/div>\n <\/div><\/div>\n\n\n\n<div class=\"wp-block-stackable-divider stk-block-divider stk-block stk-1171c16\" data-block-id=\"1171c16\"><style>.stk-1171c16 {margin-top:10px !important;margin-bottom:10px !important;}<\/style><hr class=\"stk-block-divider__hr\"\/><\/div>\n\n\n\n<h4 id=\"gspb_heading-id-gsbp-3cde8ed\" class=\"gspb_heading gspb_heading-id-gsbp-3cde8ed\"><strong>Colaboraci\u00f3n<\/strong><\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">Technology available for licensing<\/p>\n\n\n\n<div class=\"wp-block-stackable-divider stk-block-divider stk-block stk-5b6b8b7\" data-block-id=\"5b6b8b7\"><style>.stk-5b6b8b7 {margin-top:10px !important;margin-bottom:10px !important;}<\/style><hr class=\"stk-block-divider__hr\"\/><\/div>\n\n\n\n<h4 id=\"gspb_heading-id-gsbp-c794fcd\" class=\"gspb_heading gspb_heading-id-gsbp-c794fcd\"><strong>Contact<\/strong><\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">Innovation Support Unit<br>Instituto de Investigaci\u00f3n Sanitaria Puerta de Hierro<br><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>T: +34 91 191 69 37<\/li>\n\n\n\n<li>E:&nbsp;<a href=\"mailto:unidadinnovacion@idiphim.org\">unidadinnovacion@idiphim.org<\/a><\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><a href=\"https:\/\/investigacionpuertadehierro.com\/en\/common-platforms\/unidad-de-apoyo-a-la-innovacion\/\">https:\/\/investigacionpuertadehierro.com\/plataformas-comunes\/unidad-de-apoyo-a-la-innovacion<\/a><\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-greenshift-blocks-row-column gspb_row__col--8 gspb_col-id-gsbp-fbaaa4b\" id=\"gspb_col-id-gsbp-fbaaa4b\"><h2 class=\"wp-block-post-title\">Granulysin, method of obtaining it and uses<\/h2>\n\n\n<h6 id=\"inventores\" class=\"wp-block-heading\"><strong><em>Inventors<\/em><\/strong><\/h6>\n\n\n\n<p class=\"wp-block-paragraph\">Luis A. Anel Bernal; Raquel Iba\u00f1ez Perez; Patricia Guerrero Ochoa; Luis Martinez Lostao; Blanca Conde Guerri; Ram\u00f3n Hurtado Guerrero; Ana Laura Sanz Alcober; Rocio Navarro Ortiz.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Universidad de Zaragoza; Fundaci\u00f3n Agencia Aragonesa para la Investigaci\u00f3n y el Desarrollo (ARAID); Fundaci\u00f3n para la Investigaci\u00f3n Biom\u00e9dica del Hospital Universitario Puerta del Hierro (FIBHUPHM).<\/p>\n\n\n\n<h6 id=\"antecedentes\" class=\"wp-block-heading\"><strong><em>Background<\/em><\/strong><\/h6>\n\n\n\n<p class=\"wp-block-paragraph\">Granulysin (GRNLY) is a protein found in the granules of activated cytotoxic T lymphocytes (CTLs) and human natural killer (NK) cells. When GRNLY is released, high concentrations (in the micromolar range) appear in the immediate area, and its 9 kDa isoform could exert cytotoxicity. The 9 kDa GRNLY shows cytolytic activity against a wide variety of microbes, and its recombinant 9 kDa form is also cytotoxic against tumour cells. Despite the known benefits associated with the selective elimination of malignant cells, numerous practical problems limit the therapeutic use of the conjugates, including inefficient cellular uptake, low cytotoxicity and toxic effects at sites other than the tumour site.<\/p>\n\n\n\n<h6 id=\"la-invencion\" class=\"wp-block-heading\"><strong><em>La invenci\u00f3n<\/em><\/strong><\/h6>\n\n\n\n<p class=\"wp-block-paragraph\">The present invention relates to the&nbsp;<strong>polypeptide&nbsp;<\/strong><strong>granulisina<\/strong>&nbsp;<strong>(GRNLY)<\/strong>&nbsp;<strong>for use as a systemic medicine, and to a chimeric molecule comprising a recombinant antibody directed against a tumour antigen and the polypeptide (GRNLY)&nbsp;<\/strong>. The results obtained suggest that a GRNLY chimera is a good strategy for achieving its systemic administration, whereby GRNLY reaches the tumour site at concentrations high enough to exert its cytotoxic activity, especially when this chimera forms part of a single polypeptide chain and has been produced in the yeast&nbsp;<em>P<\/em><em>.&nbsp;<\/em><em>pastoris<\/em>.<\/p>\n<\/div>\n <\/div><\/div>","protected":false},"excerpt":{"rendered":"","protected":false},"author":1,"featured_media":0,"parent":4690,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_seopress_titles_title":"","_seopress_titles_desc":"","_seopress_robots_index":"","_seopress_robots_follow":"","_seopress_robots_imageindex":"","_seopress_robots_snippet":"","_seopress_robots_primary_cat":"","_seopress_robots_breadcrumbs":"","_seopress_robots_freeze_modified_date":"","_seopress_robots_custom_modified_date":"","_seopress_robots_canonical":"","_seopress_social_fb_title":"","_seopress_social_fb_desc":"","_seopress_social_fb_img":"","_seopress_social_fb_img_attachment_id":0,"_seopress_social_fb_img_width":0,"_seopress_social_fb_img_height":0,"_seopress_social_twitter_title":"","_seopress_social_twitter_desc":"","_seopress_social_twitter_img":"","_seopress_social_twitter_img_attachment_id":0,"_seopress_social_twitter_img_width":0,"_seopress_social_twitter_img_height":0,"_seopress_redirections_value":"","_seopress_redirections_enabled":"","_seopress_redirections_enabled_regex":"","_seopress_redirections_logged_status":"","_seopress_redirections_param":"","_seopress_redirections_type":0,"_seopress_analysis_target_kw":"","_gspb_post_css":"#gspb_row-id-gsbp-9c5e8bd,#gspb_row-id-gsbp-c4ea3b4{justify-content:space-between;margin-top:0;margin-bottom:0;display:flex;flex-wrap:wrap}#gspb_row-id-gsbp-c4ea3b4>.gspb_row__content{display:flex;justify-content:space-between;margin:0 auto;width:100%;flex-wrap:wrap}.gspb_row{position:relative}div[id^=gspb_col-id]{box-sizing:border-box;position:relative;padding:var(--gs-row-column-padding, 15px min(3vw, 20px))}#gspb_col-id-gsbp-47414aa.gspb_row__col--4{width:33.333333333333336%}@media (max-width:575.98px){#gspb_col-id-gsbp-47414aa.gspb_row__col--4{width:100%}}#gspb_col-id-gsbp-47414aa.gspb_row__col--4{background-color:var(--wp--preset--color--palette-color-5, var(--theme-palette-color-5, #E7EBEE))}#gspb_row-id-gsbp-9c5e8bd>.gspb_row__content{display:flex;justify-content:space-between;margin:0 auto;width:100%;flex-wrap:wrap}body.gspb-bodyfront #gspb_row-id-gsbp-9c5e8bd>.gspb_row__content,body.gspb-bodyfront #gspb_row-id-gsbp-c4ea3b4>.gspb_row__content{width:var(--theme-container-width, 1200px);max-width:var(--theme-normal-container-max-width, 1200px)}#gspb_col-id-gsbp-e677074.gspb_row__col--9{width:75%}@media (max-width:575.98px){#gspb_col-id-gsbp-e677074.gspb_row__col--9{width:100%}}#gspb_col-id-gsbp-f5c5ec0.gspb_row__col--3{width:25%}@media (max-width:575.98px){#gspb_col-id-gsbp-f5c5ec0.gspb_row__col--3{width:100%}}.gspb_row #gspb_col-id-gsbp-f5c5ec0.gspb_row__col--3{margin-right:0;margin-left:0}#gspb_col-id-gsbp-fbaaa4b.gspb_row__col--8{width:66.66666666666667%}@media (max-width:575.98px){#gspb_col-id-gsbp-fbaaa4b.gspb_row__col--8{width:100%}}","footnotes":""},"class_list":["post-6053","page","type-page","status-publish","hentry"],"blocksy_meta":{"styles_descriptor":{"styles":{"desktop":"","tablet":"","mobile":""},"google_fonts":[],"version":8}},"_links":{"self":[{"href":"https:\/\/investigacionpuertadehierro.com\/en\/wp-json\/wp\/v2\/pages\/6053","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/investigacionpuertadehierro.com\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/investigacionpuertadehierro.com\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/investigacionpuertadehierro.com\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/investigacionpuertadehierro.com\/en\/wp-json\/wp\/v2\/comments?post=6053"}],"version-history":[{"count":1,"href":"https:\/\/investigacionpuertadehierro.com\/en\/wp-json\/wp\/v2\/pages\/6053\/revisions"}],"predecessor-version":[{"id":6055,"href":"https:\/\/investigacionpuertadehierro.com\/en\/wp-json\/wp\/v2\/pages\/6053\/revisions\/6055"}],"up":[{"embeddable":true,"href":"https:\/\/investigacionpuertadehierro.com\/en\/wp-json\/wp\/v2\/pages\/4690"}],"wp:attachment":[{"href":"https:\/\/investigacionpuertadehierro.com\/en\/wp-json\/wp\/v2\/media?parent=6053"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}