{"id":5118,"date":"2026-08-20T12:12:31","date_gmt":"2026-08-20T10:12:31","guid":{"rendered":"http:\/\/localhost\/idiphisa-nueva-web-2\/?page_id=5118"},"modified":"2026-08-20T12:34:11","modified_gmt":"2026-08-20T10:34:11","slug":"animal-and-medico-surgical-research-unit-uimq-of-idiphisa","status":"publish","type":"page","link":"https:\/\/investigacionpuertadehierro.com\/en\/unidad-de-investigacion-medico-quirurgica-animalario-uimq-a-del-idiphisa\/","title":{"rendered":"IDIPHISA\u2019s Medical and Surgical Research Unit\/Animal Facility (UIMQ\/A)"},"content":{"rendered":"\n\n\n<div class=\"wp-block-greenshift-blocks-row gspb_row gspb_row-id-gsbp-3c65ca7\" id=\"gspb_row-id-gsbp-3c65ca7\"><div class=\"gspb_row__content\"> \n<div class=\"wp-block-greenshift-blocks-row-column gspb_row__col--12 gspb_col-id-gsbp-a7f42b5\" id=\"gspb_col-id-gsbp-a7f42b5\"><h2 class=\"wp-block-post-title has-text-align-left\">Unidad de Investigaci\u00f3n M\u00e9dico-Quir\u00fargica\/Animalario (UIMQ\/A) del IDIPHISA<\/h2><\/div>\n <\/div><\/div>\n\n\n\n<p class=\"wp-block-paragraph\">La Unidad de Investigaci\u00f3n M\u00e9dico-Quir\u00fargica\/Animalario (UIMQ\/A) del Instituto de Investigaci\u00f3n Puerta de Hierro-Segovia de Arana da soporte a los diferentes Servicios y Unidades de Investigaci\u00f3n del Instituto, facilitando el desarrollo y estabulaci\u00f3n de modelos animales experimentales.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">La UIMQ\/A cumple con la normativa europea (Directiva Europea 2010\/63\/UE del Parlamento Europeo y del Consejo, de 22 de septiembre de 2010, relativa a la protecci\u00f3n de los animales utilizados para fines cient\u00edficos) y nacional (Real Decreto 53\/2013, de 1 de febrero del Ministerio de la Presidencia, por el que se establecen las normas b\u00e1sicas aplicables a la protecci\u00f3n de los animales utilizados en experimentaci\u00f3n y otros fines cient\u00edficos, incluida la docencia) en cuanto al uso de animales de experimentaci\u00f3n.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Las instalaciones fueron inspeccionadas por la Secci\u00f3n T\u00e9cnica del \u00c1rea de Protecci\u00f3n Animal, dependiente de la Consejer\u00eda de Medio Ambiente, Agricultura e Interior, Direcci\u00f3n General de Agricultura, Ganader\u00eda y Alimentaci\u00f3n de la Comunidad de Madrid. En informe emitido el 5 de marzo de 2009, el Centro fue autorizado, con el n\u00famero de registro ES280800000012, como establecimiento usuario y reproductor de ratas y ratones, as\u00ed como usuario de cobayas, conejos, ovejas y cerdos en virtud de lo dispuesto en el RD 53\/2013. Posteriormente, con fecha 19 de diciembre de 2022, fue renovada la autorizaci\u00f3n.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">El Instituto cuenta con un Comit\u00e9 \u00c9tico de Experimentaci\u00f3n Animal para el cuidado y uso de animales de experimentaci\u00f3n que, con fecha 12 de marzo de 2014, fue reconocido como \u00d3rgano Habilitado para la evaluaci\u00f3n de proyectos de acuerdo al RD 53\/2013.<strong>&nbsp;<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Contacto<\/strong><br><a href=\"mailto:animalario@idiphim.org\">animalario@idiphim.org<\/a><br>91 191 77 45<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Ubicaci\u00f3n<\/strong><br>C\/ Joaqu\u00edn Rodrigo, 2<br>Edificio laboratorios, planta 0<br>28222 Majadahonda, Madrid<a href=\"https:\/\/investigacionpuertadehierro.com\/unidad-de-investigacion-medico-quirurgica-animalario-uimq-a\/#tab-506c2da29b37eded453\"><\/a><\/p>\n\n\n\n<div class=\"wp-block-stackable-divider stk-block-divider stk-block stk-2f3f823\" data-block-id=\"2f3f823\"><style>.stk-2f3f823 {min-height:40px !important;}<\/style><hr class=\"stk-block-divider__hr\"\/><\/div>\n\n\n\n<div class=\"wp-block-stackable-tabs stk-block-tabs stk-block stk-1fa08ec\" data-initial-tab=\"1\" data-block-id=\"1fa08ec\"><style>.stk-1fa08ec .stk-block-tab-content .stk-block-content .stk-block-column[hidden]{display:none !important;}.stk-1fa08ec {margin-bottom:50px !important;}<\/style><div class=\"stk-row stk-inner-blocks stk-block-content stk-block-tabs--horizontal stk-block-tabs--fade stk-content-align stk-1fa08ec-column\">\n<div class=\"wp-block-stackable-tab-labels stk-block-tab-labels stk-block stk-75e000b stk-block-background is-style-centered-pills\" data-block-id=\"75e000b\"><style>.stk-block-content.stk-block-tabs--horizontal .stk-75e000b{--tabs-flex:1 1 auto !important;}.stk-75e000b .stk-block-tabs__tab{justify-content:flex-start !important;color:#999999 !important;padding-top:8px !important;padding-right:24px 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.stk-block-tabs__tab .stk--inner-svg svg:last-child :is(g, path, rect, polygon, ellipse){fill:#777777 !important;}.stk-75e000b .stk-block-tabs__tab:not(.stk-block-tabs__tab--active):hover .stk--inner-svg svg:last-child, .stk-75e000b .stk-block-tabs__tab:not(.stk-block-tabs__tab--active):hover .stk--inner-svg svg:last-child :is(g, path, rect, polygon, ellipse){fill:#000000 !important;}.stk-75e000b .stk-block-tabs__tab.stk-block-tabs__tab--active{background:#000000 !important;}.stk-75e000b .stk-block-tabs__tab.stk-block-tabs__tab--active .stk--inner-svg svg:last-child, .stk-75e000b .stk-block-tabs__tab.stk-block-tabs__tab--active .stk--inner-svg svg:last-child :is(g, path, rect, polygon, ellipse){fill:#ffffff !important;}<\/style><div class=\"stk-block-tab-labels__wrapper\" role=\"tablist\"><button class=\"stk-block-tabs__tab\" role=\"tab\"><span class=\"stk--svg-wrapper\"><div class=\"stk--inner-svg\"><svg style=\"height:0;width:0\"><defs><linearGradient id=\"linear-gradient-75e000b\" x1=\"0\" x2=\"100%\" y1=\"0\" y2=\"0\"><stop offset=\"0%\" style=\"stop-opacity:1;stop-color:var(--linear-gradient-75-e-000-b-color-1)\"><\/stop><stop offset=\"100%\" style=\"stop-opacity:1;stop-color:var(--linear-gradient-75-e-000-b-color-2)\"><\/stop><\/linearGradient><\/defs><\/svg><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 640 512\" aria-hidden=\"true\" width=\"32\" height=\"32\"><path d=\"M96 128a128 128 0 1 1 256 0A128 128 0 1 1 96 128zM0 482.3C0 383.8 79.8 304 178.3 304h91.4C368.2 304 448 383.8 448 482.3c0 16.4-13.3 29.7-29.7 29.7H29.7C13.3 512 0 498.7 0 482.3zM609.3 512H471.4c5.4-9.4 8.6-20.3 8.6-32v-8c0-60.7-27.1-115.2-69.8-151.8c2.4-.1 4.7-.2 7.1-.2h61.4C567.8 320 640 392.2 640 481.3c0 17-13.8 30.7-30.7 30.7zM432 256c-31 0-59-12.6-79.3-32.9C372.4 196.5 384 163.6 384 128c0-26.8-6.6-52.1-18.3-74.3C384.3 40.1 407.2 32 432 32c61.9 0 112 50.1 112 112s-50.1 112-112 112z\"\/><\/svg><\/div><\/span><div class=\"stk-block-tab-labels__text has-text-align-left\"><span>Instalaciones y personal<\/span><\/div><\/button><button class=\"stk-block-tabs__tab\" role=\"tab\"><span class=\"stk--svg-wrapper\"><div class=\"stk--inner-svg\"><svg style=\"height:0;width:0\"><defs><linearGradient id=\"linear-gradient-75e000b\" x1=\"0\" x2=\"100%\" y1=\"0\" y2=\"0\"><stop offset=\"0%\" style=\"stop-opacity:1;stop-color:var(--linear-gradient-75-e-000-b-color-1)\"><\/stop><stop offset=\"100%\" style=\"stop-opacity:1;stop-color:var(--linear-gradient-75-e-000-b-color-2)\"><\/stop><\/linearGradient><\/defs><\/svg><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 448 512\" aria-hidden=\"true\" width=\"32\" height=\"32\"><path d=\"M288 0H160 128C110.3 0 96 14.3 96 32s14.3 32 32 32V196.8c0 11.8-3.3 23.5-9.5 33.5L10.3 406.2C3.6 417.2 0 429.7 0 442.6C0 480.9 31.1 512 69.4 512H378.6c38.3 0 69.4-31.1 69.4-69.4c0-12.8-3.6-25.4-10.3-36.4L329.5 230.4c-6.2-10.1-9.5-21.7-9.5-33.5V64c17.7 0 32-14.3 32-32s-14.3-32-32-32H288zM192 196.8V64h64V196.8c0 23.7 6.6 46.9 19 67.1L309.5 320h-171L173 263.9c12.4-20.2 19-43.4 19-67.1z\"\/><\/svg><\/div><\/span><div class=\"stk-block-tab-labels__text has-text-align-left\"><span>Cartera de Servicios<\/span><\/div><\/button><button class=\"stk-block-tabs__tab\" role=\"tab\"><span class=\"stk--svg-wrapper\"><div class=\"stk--inner-svg\"><svg style=\"height:0;width:0\"><defs><linearGradient id=\"linear-gradient-75e000b\" x1=\"0\" x2=\"100%\" y1=\"0\" y2=\"0\"><stop offset=\"0%\" style=\"stop-opacity:1;stop-color:var(--linear-gradient-75-e-000-b-color-1)\"><\/stop><stop offset=\"100%\" style=\"stop-opacity:1;stop-color:var(--linear-gradient-75-e-000-b-color-2)\"><\/stop><\/linearGradient><\/defs><\/svg><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 576 512\" aria-hidden=\"true\" width=\"32\" height=\"32\"><path d=\"M384 480h48c11.4 0 21.9-6 27.6-15.9l112-192c5.8-9.9 5.8-22.1 .1-32.1S555.5 224 544 224H144c-11.4 0-21.9 6-27.6 15.9L48 357.1V96c0-8.8 7.2-16 16-16H181.5c4.2 0 8.3 1.7 11.3 4.7l26.5 26.5c21 21 49.5 32.8 79.2 32.8H416c8.8 0 16 7.2 16 16v32h48V160c0-35.3-28.7-64-64-64H298.5c-17 0-33.3-6.7-45.3-18.7L226.7 50.7c-12-12-28.3-18.7-45.3-18.7H64C28.7 32 0 60.7 0 96V416c0 35.3 28.7 64 64 64H87.7 384z\"\/><\/svg><\/div><\/span><div class=\"stk-block-tab-labels__text has-text-align-left\"><span>PNTs<\/span><\/div><\/button><button class=\"stk-block-tabs__tab\" role=\"tab\"><span class=\"stk--svg-wrapper\"><div class=\"stk--inner-svg\"><svg style=\"height:0;width:0\"><defs><linearGradient id=\"linear-gradient-75e000b\" x1=\"0\" x2=\"100%\" y1=\"0\" y2=\"0\"><stop offset=\"0%\" style=\"stop-opacity:1;stop-color:var(--linear-gradient-75-e-000-b-color-1)\"><\/stop><stop offset=\"100%\" style=\"stop-opacity:1;stop-color:var(--linear-gradient-75-e-000-b-color-2)\"><\/stop><\/linearGradient><\/defs><\/svg><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 640 512\" aria-hidden=\"true\" width=\"32\" height=\"32\"><path d=\"M384 32H512c17.7 0 32 14.3 32 32s-14.3 32-32 32H398.4c-5.2 25.8-22.9 47.1-46.4 57.3V448H512c17.7 0 32 14.3 32 32s-14.3 32-32 32H320 128c-17.7 0-32-14.3-32-32s14.3-32 32-32H288V153.3c-23.5-10.3-41.2-31.6-46.4-57.3H128c-17.7 0-32-14.3-32-32s14.3-32 32-32H256c14.6-19.4 37.8-32 64-32s49.4 12.6 64 32zm55.6 288H584.4L512 195.8 439.6 320zM512 416c-62.9 0-115.2-34-126-78.9c-2.6-11 1-22.3 6.7-32.1l95.2-163.2c5-8.6 14.2-13.8 24.1-13.8s19.1 5.3 24.1 13.8l95.2 163.2c5.7 9.8 9.3 21.1 6.7 32.1C627.2 382 574.9 416 512 416zM126.8 195.8L54.4 320H199.3L126.8 195.8zM.9 337.1c-2.6-11 1-22.3 6.7-32.1l95.2-163.2c5-8.6 14.2-13.8 24.1-13.8s19.1 5.3 24.1 13.8l95.2 163.2c5.7 9.8 9.3 21.1 6.7 32.1C242 382 189.7 416 126.8 416S11.7 382 .9 337.1z\"\/><\/svg><\/div><\/span><div class=\"stk-block-tab-labels__text has-text-align-left\"><span>Legislaci\u00f3n<\/span><\/div><\/button><button class=\"stk-block-tabs__tab\" role=\"tab\"><span class=\"stk--svg-wrapper\"><div class=\"stk--inner-svg\"><svg style=\"height:0;width:0\"><defs><linearGradient id=\"linear-gradient-75e000b\" x1=\"0\" x2=\"100%\" y1=\"0\" y2=\"0\"><stop offset=\"0%\" style=\"stop-opacity:1;stop-color:var(--linear-gradient-75-e-000-b-color-1)\"><\/stop><stop offset=\"100%\" style=\"stop-opacity:1;stop-color:var(--linear-gradient-75-e-000-b-color-2)\"><\/stop><\/linearGradient><\/defs><\/svg><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 512 512\" aria-hidden=\"true\" width=\"32\" height=\"32\"><path d=\"M256 512A256 256 0 1 0 256 0a256 256 0 1 0 0 512zM216 336h24V272H216c-13.3 0-24-10.7-24-24s10.7-24 24-24h48c13.3 0 24 10.7 24 24v88h8c13.3 0 24 10.7 24 24s-10.7 24-24 24H216c-13.3 0-24-10.7-24-24s10.7-24 24-24zm40-208a32 32 0 1 1 0 64 32 32 0 1 1 0-64z\"\/><\/svg><\/div><\/span><div class=\"stk-block-tab-labels__text has-text-align-left\"><span>Procesos y enlaces de inter\u00e9s<\/span><\/div><\/button><button class=\"stk-block-tabs__tab\" role=\"tab\"><span class=\"stk--svg-wrapper\"><div class=\"stk--inner-svg\"><svg style=\"height:0;width:0\"><defs><linearGradient id=\"linear-gradient-75e000b\" x1=\"0\" x2=\"100%\" y1=\"0\" y2=\"0\"><stop offset=\"0%\" style=\"stop-opacity:1;stop-color:var(--linear-gradient-75-e-000-b-color-1)\"><\/stop><stop offset=\"100%\" style=\"stop-opacity:1;stop-color:var(--linear-gradient-75-e-000-b-color-2)\"><\/stop><\/linearGradient><\/defs><\/svg><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 640 512\" aria-hidden=\"true\" width=\"32\" height=\"32\"><path d=\"M579.8 267.7c56.5-56.5 56.5-148 0-204.5c-50-50-128.8-56.5-186.3-15.4l-1.6 1.1c-14.4 10.3-17.7 30.3-7.4 44.6s30.3 17.7 44.6 7.4l1.6-1.1c32.1-22.9 76-19.3 103.8 8.6c31.5 31.5 31.5 82.5 0 114L422.3 334.8c-31.5 31.5-82.5 31.5-114 0c-27.9-27.9-31.5-71.8-8.6-103.8l1.1-1.6c10.3-14.4 6.9-34.4-7.4-44.6s-34.4-6.9-44.6 7.4l-1.1 1.6C206.5 251.2 213 330 263 380c56.5 56.5 148 56.5 204.5 0L579.8 267.7zM60.2 244.3c-56.5 56.5-56.5 148 0 204.5c50 50 128.8 56.5 186.3 15.4l1.6-1.1c14.4-10.3 17.7-30.3 7.4-44.6s-30.3-17.7-44.6-7.4l-1.6 1.1c-32.1 22.9-76 19.3-103.8-8.6C74 372 74 321 105.5 289.5L217.7 177.2c31.5-31.5 82.5-31.5 114 0c27.9 27.9 31.5 71.8 8.6 103.9l-1.1 1.6c-10.3 14.4-6.9 34.4 7.4 44.6s34.4 6.9 44.6-7.4l1.1-1.6C433.5 260.8 427 182 377 132c-56.5-56.5-148-56.5-204.5 0L60.2 244.3z\"\/><\/svg><\/div><\/span><div class=\"stk-block-tab-labels__text has-text-align-left\"><span>Comit\u00e9 \u00c9tico de Experimentaci\u00f3n Animal<\/span><\/div><\/button><button class=\"stk-block-tabs__tab\" role=\"tab\"><span class=\"stk--svg-wrapper\"><div class=\"stk--inner-svg\"><svg style=\"height:0;width:0\"><defs><linearGradient id=\"linear-gradient-75e000b\" x1=\"0\" x2=\"100%\" y1=\"0\" y2=\"0\"><stop offset=\"0%\" style=\"stop-opacity:1;stop-color:var(--linear-gradient-75-e-000-b-color-1)\"><\/stop><stop offset=\"100%\" style=\"stop-opacity:1;stop-color:var(--linear-gradient-75-e-000-b-color-2)\"><\/stop><\/linearGradient><\/defs><\/svg><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 448 512\" aria-hidden=\"true\" width=\"32\" height=\"32\"><path d=\"M160 80c0-26.5 21.5-48 48-48h32c26.5 0 48 21.5 48 48V432c0 26.5-21.5 48-48 48H208c-26.5 0-48-21.5-48-48V80zM0 272c0-26.5 21.5-48 48-48H80c26.5 0 48 21.5 48 48V432c0 26.5-21.5 48-48 48H48c-26.5 0-48-21.5-48-48V272zM368 96h32c26.5 0 48 21.5 48 48V432c0 26.5-21.5 48-48 48H368c-26.5 0-48-21.5-48-48V144c0-26.5 21.5-48 48-48z\"\/><\/svg><\/div><\/span><div class=\"stk-block-tab-labels__text has-text-align-left\"><span>Plan de Instauraci\u00f3n de la Cultura del Cuidado<\/span><\/div><\/button><\/div><\/div>\n\n\n\n<div class=\"wp-block-stackable-tab-content stk-block-tab-content stk-block stk-b4c5087\" data-block-id=\"b4c5087\"><div class=\"stk-row stk-inner-blocks stk-block-content stk-content-align stk-b4c5087-column\">\n<div class=\"wp-block-stackable-column stk-block-column stk-column stk-block stk-b8a50db\" data-v=\"4\" role=\"tabpanel\" data-block-id=\"b8a50db\"><div class=\"stk-column-wrapper stk-block-column__content stk-container stk-b8a50db-container stk--no-background stk--no-padding\"><div class=\"stk-block-content stk-inner-blocks stk-b8a50db-inner-blocks\">\n<p class=\"wp-block-paragraph\">La UIMQ\/A, situada en la plata 0 del edificio de investigaci\u00f3n y laboratorios, cuenta con una superficie aproximada de 700 m<sup>2<\/sup>. Est\u00e1 controlada por un circuito de videovigilancia conectado a la Central de Seguridad del Hospital y tiene el acceso restringido a sus instalaciones. Se encuentra dividida en las siguientes \u00e1reas:<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Animalario:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Una sala de cuarentena con una recepci\u00f3n de animales.<\/li>\n\n\n\n<li>Dos \u00e1reas de estabulaci\u00f3n de roedores, cobayas y conejos. Est\u00e1n constituidas por una sala de distribuci\u00f3n y trabajo y distintas salas de estabulaci\u00f3n:\n<ul class=\"wp-block-list\">\n<li>\u2013 Dos para ratas<\/li>\n\n\n\n<li>\u2013 Dos para ratones<\/li>\n\n\n\n<li>\u2013 Una para conejos y cobayas<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">Todas las salas de estabulaci\u00f3n tienen control de ciclo de luz, temperatura y humedad. Adem\u00e1s, est\u00e1n dotadas con racks ventilados individualmente, microaisladores de polieterimida U-TEMP de distintos tama\u00f1os y especies (ratas, rat\u00f3n y cobaya) y una cabina de transferencia para el manejo de animales SPF e inmunosuprimidos.<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Dos salas de estabulaci\u00f3n para grandes animales.<\/li>\n\n\n\n<li>Una sala de limpieza y desinfecci\u00f3n de equipamiento dotada de dos lavadoras de jaulas.<\/li>\n\n\n\n<li>Tres almacenes para material, pienso y lecho y equipamiento.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Laboratorios y quir\u00f3fanos experimentales:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Una sala de trabajo experimental para roedores dotada de dos microscopios quir\u00fargicos.<\/li>\n\n\n\n<li>Dos quir\u00f3fanos experimentales con aclimataci\u00f3n y presi\u00f3n positiva independiente, dotados de estaciones anest\u00e9sicas y equipos de monitorizaci\u00f3n vital.<\/li>\n\n\n\n<li>Un laboratorio multifuncional.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">La capacidad total de animales de la UIMQ\/A permite la estabulaci\u00f3n de 700 ratas, 900 ratones, 40 cobayas, 6 conejos y 6 cerdos\/ovejas.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Personal<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">El personal adscrito a la UIMQ\/A cuenta con la capacitaci\u00f3n de las funciones necesarias para el manejo y cuidado de animales de experimentaci\u00f3n de acuerdo con la Orden ECC\/566\/2015, de 20 de marzo, por la que se establecen los requisitos de formaci\u00f3n que debe reunir el personal que manipule animales utilizados, criados o suministrados para experimentaci\u00f3n y otros fines cient\u00edficos, incluida la docencia.<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Veterinario designado y responsable&nbsp;<em>\u00abin situ\u00bb<\/em>&nbsp;del bienestar animal.\n<ul class=\"wp-block-list\">\n<li>\u2013 Mart\u00edn Santos Gonz\u00e1lez<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li>Cuidador a tiempo parcial.<\/li>\n<\/ul>\n<\/div><\/div><\/div>\n\n\n\n<div class=\"wp-block-stackable-column stk-block-column stk-column stk-block stk-502b907\" data-v=\"4\" role=\"tabpanel\" data-block-id=\"502b907\"><div class=\"stk-column-wrapper stk-block-column__content stk-container stk-502b907-container stk--no-background stk--no-padding\"><div class=\"stk-block-content stk-inner-blocks stk-502b907-inner-blocks\">\n<p class=\"wp-block-paragraph\"><strong>Investigaci\u00f3n<\/strong><\/p>\n\n\n\n<ol class=\"wp-block-list\">\n<li>Orientaci\u00f3n y soporte en investigaci\u00f3n con animales de experimentaci\u00f3n.<\/li>\n\n\n\n<li>Desarrollo de modelos con animales de experimentaci\u00f3n en investigaci\u00f3n.<\/li>\n\n\n\n<li>Desarrollo de proyectos propios y de terceros.<\/li>\n\n\n\n<li>Soporte para el tratamiento de los resultados de proyectos desarrollados con animales de experimentaci\u00f3n.<\/li>\n<\/ol>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Formaci\u00f3n<\/strong><\/p>\n\n\n\n<ol class=\"wp-block-list\">\n<li>Desarrollo de modelos con animales de experimentaci\u00f3n en la docencia m\u00e9dico-quir\u00fargica.<\/li>\n\n\n\n<li>Organizaci\u00f3n y desarrollo de cursos con simuladores, piezas anat\u00f3micas y animales de experimentaci\u00f3n.<\/li>\n\n\n\n<li>Apoyo de la Unidad de Simulaci\u00f3n.<\/li>\n\n\n\n<li>Apoyo de la Formaci\u00f3n Continuada del personal.<\/li>\n\n\n\n<li>Formaci\u00f3n Continuada para el mantenimiento de la capacitaci\u00f3n de las funciones para el manejo de animales de experimentaci\u00f3n.<\/li>\n<\/ol>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Gesti\u00f3n<\/strong><\/p>\n\n\n\n<ol class=\"wp-block-list\">\n<li>Gesti\u00f3n sanitaria y del bienestar de los animales alojados en el animalario.<\/li>\n\n\n\n<li>Participaci\u00f3n en Comit\u00e9s (Comit\u00e9 \u00c9tico de Experimentaci\u00f3n Animal, \u00d3rgano Habilitado, Comit\u00e9 de Seguridad Biol\u00f3gica).<\/li>\n\n\n\n<li>Gesti\u00f3n de proyectos desarrollados con animales de experimentaci\u00f3n.<\/li>\n\n\n\n<li>Gesti\u00f3n del Grupo de Investigaci\u00f3n en Modelos Experimentales.<\/li>\n\n\n\n<li>Relaci\u00f3n con otros Centros experimentales.<\/li>\n\n\n\n<li>Relaci\u00f3n, para el reporte de informes estad\u00edsticos y de aplicaci\u00f3n, con el \u00c1rea de Protecci\u00f3n Animal de la Comunidad de Madrid (Programa Hamellin) y con la Uni\u00f3n Europea (Programa Alures).<\/li>\n<\/ol>\n<\/div><\/div><\/div>\n\n\n\n<div class=\"wp-block-stackable-column stk-block-column stk-column stk-block stk-559faaf\" data-v=\"4\" role=\"tabpanel\" data-block-id=\"559faaf\"><div class=\"stk-column-wrapper stk-block-column__content stk-container stk-559faaf-container stk--no-background stk--no-padding\"><div class=\"stk-block-content stk-inner-blocks stk-559faaf-inner-blocks\">\n<p class=\"wp-block-paragraph\">Puede consultar los PNTs accediendo a la Intranet del IDIPHISA:<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><a href=\"https:\/\/intranet.idiphim.org\/unidad-de-investigacion-medico-quirurgica-animalario-uimq-a-del-idiphisa\">https:\/\/intranet.idiphim.org\/unidad-de-investigacion-medico-quirurgica-animalario-uimq-a-del-idiphisa<\/a><\/p>\n<\/div><\/div><\/div>\n\n\n\n<div class=\"wp-block-stackable-column stk-block-column stk-column stk-block stk-5ec72e2\" data-v=\"4\" role=\"tabpanel\" data-block-id=\"5ec72e2\"><div class=\"stk-column-wrapper stk-block-column__content stk-container stk-5ec72e2-container stk--no-background stk--no-padding\"><div class=\"stk-block-content stk-inner-blocks stk-5ec72e2-inner-blocks\">\n<div class=\"wp-block-greenshift-blocks-iconlist gspb_iconsList gspb_iconsList-id-gsbp-8acfc32\" id=\"gspb_iconsList-id-gsbp-8acfc32\"><div class=\"gspb_iconsList__item\" data-id=\"0\"><a class=\"gspb_iconsList__link\" href=\"https:\/\/investigacionpuertadehierro.com\/wp-content\/uploads\/2026\/08\/Orden-CNU\uf022120\uf0222025.pdf\" target=\"_blank\" rel=\"noopener\"><\/a><img decoding=\"async\" src=\"https:\/\/investigacionpuertadehierro.com\/wp-content\/uploads\/2026\/03\/pdf.png\"\/><span class=\"gspb_iconsList__item__text\"><strong><em><strong><a href=\"https:\/\/investigacionpuertadehierro.com\/wp-content\/uploads\/2026\/08\/Orden-CNU\uf022120\uf0222025.pdf\" data-type=\"link\" data-id=\"https:\/\/investigacionpuertadehierro.com\/wp-content\/uploads\/legacy\/2019\/endorsement_ES_IDIPHISA_02282018.pdf\" target=\"_blank\" rel=\"noopener\">Orden CNU 120 2025<\/a><\/strong><\/em><\/strong><\/span><\/div><\/div>\n\n\n\n<div class=\"wp-block-greenshift-blocks-iconlist gspb_iconsList gspb_iconsList-id-gsbp-2525ba6\" id=\"gspb_iconsList-id-gsbp-2525ba6\"><div class=\"gspb_iconsList__item\" data-id=\"0\"><a class=\"gspb_iconsList__link\" href=\"https:\/\/investigacionpuertadehierro.com\/wp-content\/uploads\/2026\/08\/Orden-ECC\uf022566\uf0222015.pdf\" target=\"_blank\" rel=\"noopener\"><\/a><img decoding=\"async\" src=\"https:\/\/investigacionpuertadehierro.com\/wp-content\/uploads\/2026\/03\/pdf.png\"\/><span class=\"gspb_iconsList__item__text\"><strong><em><strong><a href=\"https:\/\/investigacionpuertadehierro.com\/wp-content\/uploads\/2026\/08\/Orden-ECC\uf022566\uf0222015.pdf\" data-type=\"link\" data-id=\"https:\/\/investigacionpuertadehierro.com\/wp-content\/uploads\/legacy\/2019\/endorsement_ES_IDIPHISA_02282018.pdf\" target=\"_blank\" rel=\"noopener\">Orden ECC 566 2015<\/a><\/strong><\/em><\/strong><\/span><\/div><\/div>\n\n\n\n<div class=\"wp-block-greenshift-blocks-iconlist gspb_iconsList gspb_iconsList-id-gsbp-700f630\" id=\"gspb_iconsList-id-gsbp-700f630\"><div class=\"gspb_iconsList__item\" data-id=\"0\"><a class=\"gspb_iconsList__link\" href=\"https:\/\/investigacionpuertadehierro.com\/wp-content\/uploads\/2026\/08\/RD-53_2013.pdf\" target=\"_blank\" rel=\"noopener\"><\/a><img decoding=\"async\" src=\"https:\/\/investigacionpuertadehierro.com\/wp-content\/uploads\/2026\/03\/pdf.png\"\/><span class=\"gspb_iconsList__item__text\"><strong><em><strong><a href=\"https:\/\/investigacionpuertadehierro.com\/wp-content\/uploads\/2026\/08\/RD-53_2013.pdf\" data-type=\"link\" data-id=\"https:\/\/investigacionpuertadehierro.com\/wp-content\/uploads\/legacy\/2019\/endorsement_ES_IDIPHISA_02282018.pdf\" target=\"_blank\" rel=\"noopener\">RD 53_2013<\/a><\/strong><\/em><\/strong><\/span><\/div><\/div>\n<\/div><\/div><\/div>\n\n\n\n<div class=\"wp-block-stackable-column stk-block-column stk-column stk-block stk-8av4jkq\" data-v=\"4\" role=\"tabpanel\" data-block-id=\"8av4jkq\"><div class=\"stk-column-wrapper stk-block-column__content stk-container stk-8av4jkq-container stk--no-background stk--no-padding\"><div class=\"stk-block-content stk-inner-blocks stk-8av4jkq-inner-blocks\">\n<p class=\"wp-block-paragraph\"><strong>Reconocimiento de la capacitaci\u00f3n para manejar animales de experimentaci\u00f3n<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Los investigadores\/as que est\u00e9n en posesi\u00f3n de los cursos para manejar animales de experimentaci\u00f3n, hayan realizado las pr\u00e1cticas bajo supervisi\u00f3n y deseen solicitar el reconocimiento de la capacitaci\u00f3n en las funciones a, b y\/o c pueden hacerlo descarg\u00e1ndose el siguiente documento:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><em><a href=\"https:\/\/investigacionpuertadehierro.com\/wp-content\/uploads\/legacy\/2025\/Certificado-de-practicas-bajo-supervision.docx\" data-type=\"attachment\" data-id=\"1438\">Certificado de pr\u00e1cticas bajo supervisi\u00f3n<\/a>.<\/em><\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">Una vez cumplimentado, se tramitar\u00e1 en el \u00c1rea de Protecci\u00f3n Animal de la CAM enviando el certificado del curso y el documento que acredite la realizaci\u00f3n de las pr\u00e1cticas bajo supervisi\u00f3n siguiendo las instrucciones que podr\u00e1n encontrar en el documento\u00a0<em><a href=\"https:\/\/investigacionpuertadehierro.com\/wp-content\/uploads\/legacy\/2025\/Instrucciones-reconocimiento-capacitacion.pdf\" data-type=\"attachment\" data-id=\"1452\">Instrucciones reconocimiento capacitaci\u00f3n<\/a>.<\/em><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Si la capacitaci\u00f3n que desean solicitar es para la funci\u00f3n d, no ser\u00e1 necesario realizar las pr\u00e1cticas bajo supervisi\u00f3n. La tramitaci\u00f3n en el \u00c1rea de Protecci\u00f3n Animal de la CAM ser\u00e1 enviando el certificado del curso y una copia del t\u00edtulo de grado, siguiendo las instrucciones que podr\u00e1n encontrar en el documento\u00a0<em><a href=\"https:\/\/investigacionpuertadehierro.com\/wp-content\/uploads\/legacy\/2025\/Instrucciones-reconocimiento-capacitacion.pdf\" data-type=\"attachment\" data-id=\"1452\">Instrucciones reconocimiento capacitaci\u00f3n<\/a>.<\/em><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Mantenimiento de la capacitaci\u00f3n para manejar animales de experimentaci\u00f3n<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Los investigadores\/as a los que se les caduque el reconocimiento de la capacitaci\u00f3n en cualquiera de las funciones, pueden realizar el tr\u00e1mite de mantenimiento de la capacitaci\u00f3n en el \u00c1rea de Protecci\u00f3n Animal de la CAM enviando los certificados de los cursos que acrediten las horas para el mantenimiento de la capacitaci\u00f3n de dichas funciones, siguiendo las instrucciones que podr\u00e1n encontrar en el documento\u00a0<em><a href=\"https:\/\/investigacionpuertadehierro.com\/wp-content\/uploads\/2026\/08\/Instrucciones-mantenimiento-capacitacion.pdf\">Instrucciones mantenimiento capacitaci\u00f3n.<\/a><\/em><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Autorizaci\u00f3n experimentaci\u00f3n animal<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Los investigadores\/as que requieran un informe del CEEA y\/o \u00d3rgano Habilitado deber\u00e1n descargarse los siguientes documentos:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><em><a href=\"https:\/\/investigacionpuertadehierro.com\/wp-content\/uploads\/2026\/08\/Propuesta-proyecto-solicitud-evaluacion-y-memoria-de-contenidos-CEEA_OH.doc\">Propuesta proyecto, solicitud evaluaci\u00f3n y memoria de contenidos CEEA_OH<\/a><\/em><\/li>\n\n\n\n<li><em><a href=\"https:\/\/investigacionpuertadehierro.com\/wp-content\/uploads\/2026\/08\/alures_RNT_modelo_version_1.1-002.xlsx\">alures_RNT_modelo_version_1.1 (002)<\/a><\/em><\/li>\n\n\n\n<li><em><a href=\"https:\/\/investigacionpuertadehierro.com\/wp-content\/uploads\/2026\/08\/Recommendations-for-NTS.pdf\">Recommendations for NTS<\/a><\/em><\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">Una vez cumplimentados deber\u00e1 enviarlos por correo electr\u00f3nico al secretario\/a del CEEA, solicitando la evaluaci\u00f3n del proyecto de investigaci\u00f3n y\/o docencia, indic\u00e1ndolo as\u00ed en el asunto del correo electr\u00f3nico.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Evaluado el proyecto, se remitir\u00e1 al interesado\/a los informes para su tramitaci\u00f3n en el \u00c1rea de Protecci\u00f3n Animal de la CAM siguiendo las instrucciones que podr\u00e1n encontrar en el documento\u00a0<em><a href=\"https:\/\/investigacionpuertadehierro.com\/wp-content\/uploads\/2026\/08\/Instrucciones-autorizacion-experimentacion-animal.pdf\" data-type=\"link\" data-id=\"https:\/\/investigacionpuertadehierro.com\/wp-content\/uploads\/2026\/08\/Instrucciones-autorizacion-experimentacion-animal.pdf\">Instrucciones autorizaci\u00f3n experimentaci\u00f3n animal<\/a>.<\/em><\/p>\n<\/div><\/div><\/div>\n\n\n\n<div class=\"wp-block-stackable-column stk-block-column stk-column stk-block stk-2211e0a\" data-v=\"4\" role=\"tabpanel\" data-block-id=\"2211e0a\"><div class=\"stk-column-wrapper stk-block-column__content stk-container stk-2211e0a-container stk--no-background stk--no-padding\"><div class=\"stk-block-content stk-inner-blocks stk-2211e0a-inner-blocks\">\n<p class=\"wp-block-paragraph\"><a href=\"https:\/\/investigacionpuertadehierro.com\/comites\/#tab-ea5cdc1d52750df48e4\">Comit\u00e9 \u00c9tico de Experimentaci\u00f3n Animal del IDIPHISA<\/a><\/p>\n<\/div><\/div><\/div>\n\n\n\n<div class=\"wp-block-stackable-column stk-block-column stk-column stk-block stk-f065dcc\" data-v=\"4\" role=\"tabpanel\" data-block-id=\"f065dcc\"><div class=\"stk-column-wrapper stk-block-column__content stk-container stk-f065dcc-container stk--no-background stk--no-padding\"><div class=\"stk-block-content stk-inner-blocks stk-f065dcc-inner-blocks\">\n<div class=\"wp-block-greenshift-blocks-iconlist gspb_iconsList gspb_iconsList-id-gsbp-b3e5f60\" id=\"gspb_iconsList-id-gsbp-b3e5f60\"><div class=\"gspb_iconsList__item\" data-id=\"0\"><a class=\"gspb_iconsList__link\" href=\"https:\/\/investigacionpuertadehierro.com\/wp-content\/uploads\/legacy\/2025\/8.-Plan-de-instauracion-de-la-Cultura-del-Cuidado.docx\" target=\"_blank\" rel=\"noopener\"><\/a><img decoding=\"async\" src=\"https:\/\/investigacionpuertadehierro.com\/wp-content\/uploads\/2026\/03\/pdf.png\"\/><span class=\"gspb_iconsList__item__text\"><strong><em><strong><strong><a href=\"https:\/\/investigacionpuertadehierro.com\/wp-content\/uploads\/legacy\/2025\/8.-Plan-de-instauracion-de-la-Cultura-del-Cuidado.docx\" data-type=\"attachment\" data-id=\"1290\" target=\"_blank\" rel=\"noopener\">Plan de instauraci\u00f3n de la Cultura del Cuidado<\/a><\/strong><\/strong><\/em><\/strong><\/span><\/div><\/div>\n<\/div><\/div><\/div>\n\n\n\n<div class=\"wp-block-stackable-column stk-block-column stk-column stk-block stk-6714c39\" data-v=\"4\" role=\"tabpanel\" data-block-id=\"6714c39\"><div class=\"stk-column-wrapper stk-block-column__content stk-container stk-6714c39-container stk--no-background stk--no-padding\"><div class=\"stk-block-content stk-inner-blocks stk-6714c39-inner-blocks\">\n<div id=\"funcionamiento\"><\/div><h5 id=\"gspb_heading-id-gsbp-47f00c3\" class=\"gspb_heading gspb_heading-id-gsbp-47f00c3 \">PROYECTOS EN CURSO<\/h5>\n\n\n\n<ul class=\"wp-block-list\">\n<li>2025-actualidad: Papel de la microbiota intestinal en la respuesta a la quimio-inmunoterapia en c\u00e1ncer de pulm\u00f3n de c\u00e9lulas no peque\u00f1as.&nbsp;<strong>PI24\/01725&nbsp;<\/strong>(ISCIII). Cuant\u00eda:&nbsp;<strong>340.000 \u20ac<\/strong>.&nbsp;<strong>IP<\/strong>:&nbsp;<strong>Atocha Romero.<\/strong><\/li>\n\n\n\n<li>2022-actualidad: Validaci\u00f3n cl\u00ednica de un sistema para detectar translocaciones de ALK en ves\u00edculas extracelulares en plasma III.&nbsp;<strong>DTS21\/00124&nbsp;<\/strong>(ISCIII). Cuant\u00eda:&nbsp;<strong>88.550,00\u20ac&nbsp;<\/strong>(presupuesto exclusivo para el centro de la IP).&nbsp;<strong>IP. Coordinador&nbsp;<\/strong>(estudio multic\u00e9ntrico):&nbsp;<strong>Atocha Romero.<\/strong><\/li>\n\n\n\n<li>2022-actualidad:&nbsp;<em>Biomarkers4Cure<\/em>. Biomarcadores predictivos de respuesta a combinaciones de inmunoterapia m\u00e1s quimioterapia neoadyuvante en pacientes con c\u00e1ncer de pulm\u00f3n operable.&nbsp;<strong>PI21\/01500&nbsp;<\/strong>(ISCIII). Cuant\u00eda:&nbsp;<strong>266.00 \u20ac. IP: Atocha Romero.<\/strong><\/li>\n\n\n\n<li>2020-actualidad: Investigador colaborador en el proyecto RETOS-COLABORACI\u00d3N titulado \u201cBLI-O. Desarrollo de marcadores moleculares en biopsia liquida para larga supervivencia en oncoinmunoterapia (I-O)\u201d.&nbsp;<strong>RTC2019- 007359-<\/strong>1<strong>. IP:Mariano Provencio.<\/strong><\/li>\n\n\n\n<li>2022-actualidad<strong>:&nbsp;<\/strong>Determinaci\u00f3n de mutaciones DDR en una cohorte de pacientes con CPRCm mediante biopsia l\u00edquida (ctDNA). Concordancia con el estudio germinal y en tejido tumoral.&nbsp;<strong>PI 175\/21<\/strong>.&nbsp;<strong>IP: Atocha Romero<\/strong><\/li>\n\n\n\n<li>2023-2025: Quimio-inmunoterapia en estadios localmente avanzados deCPCNP: validaci\u00f3n de marcadores derivados del ctDNA y el microambiente tumoral. Funding body and call: ISCIII (AES 2022). PI22\/01223. Cuant\u00eda:&nbsp;<strong>268.620<\/strong>&nbsp;\u20ac.&nbsp;<strong>I.P: Mariano Provencio (HUPH).<\/strong><\/li>\n<\/ul>\n\n\n\n<div id=\"funcionamiento\"><\/div><h5 id=\"gspb_heading-id-gsbp-81c23ca\" class=\"gspb_heading gspb_heading-id-gsbp-81c23ca \">PUBLICACIONES SELECCIONADAS<\/h5>\n\n\n\n<ol class=\"wp-block-list\">\n<li><a href=\"https:\/\/doi.org\/10.1056\/NEJMoa2215530\">Provencio M, Nadal E, Gonz\u00e1lez-Larriba JL, Mart\u00ednez-Mart\u00ed A, Bernab\u00e9 R, Bosch-Barrera J, Casal-Rubio J, Calvo V, Insa A, Ponce S, Reguart N, de Castro J, Mosquera J, Cobo M, Aguilar A, L\u00f3pez Vivanco G, Camps C, L\u00f3pez-Castro R, Mor\u00e1n T, Barneto I, Rodr\u00edguez-Abreu D, Serna-Blasco R, Ben\u00edtez R, Aguado de la Rosa C, Palmero R, Hernando-Trancho F, Mart\u00edn-L\u00f3pez J, Cruz-Berm\u00fadez A, Massuti B, Romero A. Perioperative Nivolumab and Chemotherapy in Stage III Non-Small-Cell Lung Cancer. N Engl J Med. 2023 Aug 10;389(6):504-513. doi: 10.1056\/NEJMoa2215530. Epub 2023 Jun 28. PMID: 37379158.<img loading=\"lazy\" decoding=\"async\" width=\"30\" height=\"30\" src=\"http:\/\/investigacionpuertadehierro.com\/wp-content\/uploads\/2019\/06\/icon_paper.jpg\" alt=\"\"><\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1001\/jamaoncol.2022.5959\">Provencio M, et al. Atezolizumab Plus Bevacizumab as First-line Treatment for Patients With Metastatic Nonsquamous Non-Small Cell Lung Cancer With High Tumor Mutation Burden: A Nonrandomized Controlled Trial. 2022. JAMA Oncol. Online ahead of print. doi: 10.1001\/jamaoncol.2022.5959.<img loading=\"lazy\" decoding=\"async\" width=\"30\" height=\"30\" src=\"http:\/\/investigacionpuertadehierro.com\/wp-content\/uploads\/2019\/06\/icon_paper.jpg\" alt=\"\"><\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1200\/JCO.21.02660\">Provencio M et al. Overall Survival and Biomarker Analysis of Neoadjuvant Nivolumab Plus Chemotherapy in Operable Stage IIIA Non-Small-Cell Lung Cancer (NADIM phase II trial). J Clin Oncol, 40(25):2924 2933. doi: 10.1200\/JCO.21.02660<img loading=\"lazy\" decoding=\"async\" width=\"30\" height=\"30\" src=\"http:\/\/investigacionpuertadehierro.com\/wp-content\/uploads\/2019\/06\/icon_paper.jpg\" alt=\"\"><\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1093\/clinchem\/hvac021\">S\u00e1nchez-Herrero E, et al. ALK-Fusion Transcripts Can Be Detected in Extracellular Vesicles (EVs) from Nonsmall Cell Lung Cancer Cell Lines and Patient Plasma: Toward EV-Based Noninvasive Testing. Clin Chem. 2022 Mar 28;hvac021.<img loading=\"lazy\" decoding=\"async\" width=\"30\" height=\"30\" src=\"http:\/\/investigacionpuertadehierro.com\/wp-content\/uploads\/2019\/06\/icon_paper.jpg\" alt=\"\"><\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1158\/1078-0432.CCR-21-1200\">Casarrubios M,et al. Pretreatment Tissue TCR Repertoire Evenness Is Associated with Complete Pathologic Response in Patients with NSCLC Receiving Neoadjuvant Chemoimmunotherapy. 2021. Clin Cancer Res, 27(21):5878-5890. doi: 10.1158\/1078-0432.CCR-21-1200.<img loading=\"lazy\" decoding=\"async\" width=\"30\" height=\"30\" src=\"http:\/\/investigacionpuertadehierro.com\/wp-content\/uploads\/2019\/06\/icon_paper.jpg\" alt=\"\"><\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1136\/jitc-2021-002804\">Sierra-Rodero B, Cruz-Berm\u00fadez A (CA), Nadal E, \u2026 Provencio M (CA) (26\/26). Clinical and molecular parameters associated to pneumonitis development in non-small-cell lung cancer patients receiving chemoimmunotherapy from NADIM trial. J Immunother Cancer, 9(8): e002804. doi: 10.1136\/jitc-2021-002804.<img loading=\"lazy\" decoding=\"async\" width=\"30\" height=\"30\" src=\"http:\/\/investigacionpuertadehierro.com\/wp-content\/uploads\/2019\/06\/icon_paper.jpg\" alt=\"\"><\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1002\/1878-0261.13033\">S\u00e1nchez-Herrero E, et al. NGS-based liquid-biopsy profiling identifies mechanisms of resistance to ALK inhibitors: a step towards personalized NSCLC treatment. Mol Oncol. 2021 May 31. doi: 10.1002\/1878-0261.13033<img loading=\"lazy\" decoding=\"async\" width=\"30\" height=\"30\" src=\"http:\/\/investigacionpuertadehierro.com\/wp-content\/uploads\/2019\/06\/icon_paper.jpg\" alt=\"\"><\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1002\/ctm2.491\">Laza-Briviesca R, et al. Blood biomarkers associated to complete pathological response on NSCLC patients treated with neoadjuvant Chemoimmunotherapy included in NADIM clinical trial. 2021. Clin Transl Med, 11(7):e491. doi: 10.1002\/ctm2.491.<img loading=\"lazy\" decoding=\"async\" width=\"30\" height=\"30\" src=\"http:\/\/investigacionpuertadehierro.com\/wp-content\/uploads\/2019\/06\/icon_paper.jpg\" alt=\"\"><\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1515\/cclm-2020-1465\">P\u00e9rez-Barrios C, et al. ctDNA from body fluids is an adequate source for EGFR biomarker testing in advanced lung adenocarcinoma. Clin Chem Lab Med. Clin Chem Lab Med. 2021 Mar 11;59(7):1221-1229<img loading=\"lazy\" decoding=\"async\" width=\"30\" height=\"30\" src=\"http:\/\/investigacionpuertadehierro.com\/wp-content\/uploads\/2019\/06\/icon_paper.jpg\" alt=\"\"><\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1016\/j.ejca.2021.02.031\">Provencio M et al. Analysis of circulating tumour DNA to identify patients with epidermal growth factor receptor positive non-small cell lung cancer who might benefit from sequential tyrosine kinase inhibitor treatment. Eur J Cancer, 149:61-72. doi: 10.1016\/j.ejca.2021.02.031.<img loading=\"lazy\" decoding=\"async\" width=\"30\" height=\"30\" src=\"http:\/\/investigacionpuertadehierro.com\/wp-content\/uploads\/2019\/06\/icon_paper.jpg\" alt=\"\"><\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1016\/S1470-2045(20)30453-8\">Provencio M et al. Neoadjuvant chemotherapy and nivolumab in resectable non-small-cell lung cancer (NADIM): an open label, multicentre, single-arm, phase 2 trial. 2020. Lancet Oncol, 21(11):1413 1422. doi: 1016\/S1470-2045(20)30453-8.<img loading=\"lazy\" decoding=\"async\" width=\"30\" height=\"30\" src=\"http:\/\/investigacionpuertadehierro.com\/wp-content\/uploads\/2019\/06\/icon_paper.jpg\" alt=\"\"><\/a><\/li>\n<\/ol>\n<\/div><\/div><\/div>\n<\/div><\/div>\n<\/div><\/div>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n","protected":false},"excerpt":{"rendered":"<p>La Unidad de Investigaci\u00f3n M\u00e9dico-Quir\u00fargica\/Animalario (UIMQ\/A) del Instituto de Investigaci\u00f3n Puerta de Hierro-Segovia de Arana da soporte a los diferentes Servicios y Unidades de Investigaci\u00f3n del Instituto, facilitando el desarrollo y estabulaci\u00f3n de modelos animales experimentales. La UIMQ\/A cumple con la normativa europea (Directiva Europea 2010\/63\/UE del Parlamento Europeo y del Consejo, de 22 de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_seopress_titles_title":"","_seopress_titles_desc":"","_seopress_robots_index":"","_seopress_robots_follow":"","_seopress_robots_imageindex":"","_seopress_robots_snippet":"","_seopress_robots_primary_cat":"","_seopress_robots_breadcrumbs":"","_seopress_robots_freeze_modified_date":"","_seopress_robots_custom_modified_date":"","_seopress_robots_canonical":"","_seopress_social_fb_title":"","_seopress_social_fb_desc":"","_seopress_social_fb_img":"","_seopress_social_fb_img_attachment_id":0,"_seopress_social_fb_img_width":0,"_seopress_social_fb_img_height":0,"_seopress_social_twitter_title":"","_seopress_social_twitter_desc":"","_seopress_social_twitter_img":"","_seopress_social_twitter_img_attachment_id":0,"_seopress_social_twitter_img_width":0,"_seopress_social_twitter_img_height":0,"_seopress_redirections_value":"","_seopress_redirections_enabled":"","_seopress_redirections_enabled_regex":"","_seopress_redirections_logged_status":"","_seopress_redirections_param":"","_seopress_redirections_type":0,"_seopress_analysis_target_kw":"","_gspb_post_css":"#gspb_row-id-gsbp-3c65ca7{justify-content:space-between;margin-top:0;margin-bottom:0;display:flex;flex-wrap:wrap}#gspb_row-id-gsbp-3c65ca7>.gspb_row__content{display:flex;justify-content:space-between;margin:0 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